Category: Science-Biology/Chemistry/Physics

Car Wars – BONUS POST

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The Bonus Book of the Week is “Car Wars, The Rise, the Fall, and the Resurgence of the Electric Car” by John J. Fialka, published in 2015. This volume provided a brief history of how manufacturing and sales of renewable-energy vehicles has been evolving in the last few decades. Clearly, the author wrote about relevant subjects from documents, and people to which he had easy access.

The (lazy?) author dismissed the electric cars of the late 1800’s in two sentences, saying they were obsolesced by 1920 via an innovation by engineer Charles Kettering; an electric ignition system replaced a burdensome hand crank in gas-powered cars, especially in the Cadillac of 1912, and then just like that, everyone started buying gas-powered cars. A propaganda war, profiteering and politics likely played a role in that major development in standard-setting in transportation, but the reader wouldn’t learn that from this book.

Anyway, in the 1980’s, previously competing automakers were initially compelled to form alliances to comply with car-emissions limits and meet deadlines set by U.S. laws, especially in the state of California. They shared info on electric vehicle (EV) technology. Over the years, when the deadlines were relaxed by pro-business politicians, the automakers parted ways, and independently pursued only the specific projects they felt would be profitable. Environment be damned.

In 1990, near the campus of the California Institute of Technology, when drivers tested the plug-in recharging feature of the General Motors Impact in their personal garages, their neighbors’ garage doors and TV sets went crazy, because the recharger was actually a huge radio transmitter.

In October 1995, Japan’s Toyota beat American carmakers to the punch when it showed off its hybrid Prius, that got 70 miles per gallon of gas. Of course Japan, of all the industrialized countries in the world, is significantly more motivated to seek efficient, renewable energy sources for its transportation modes– for the sake of its economic survival.

In the late 1990’s in a few select places in California and Arizona, super-rich males leased the first few models of EVs, because the cars had the attractive features of fast acceleration and high velocity; high gas mileage was a secondary benefit.

Meanwhile, in the single-digit 2000’s, a group named the California Fuel Cell Partnership was formed. It consisted of Geoffrey Ballard, Daimler, and Ford, who were working on a competing vehicle that uses fuel cells– whose mechanical components chemically alter water molecules. The selling points for those cars, once the technology’s commercial application is perfected, include: zero-emissions and the ability to fill up the car at existing gas stations. However, oil companies would supply hydrogen tanks.

Read the book to learn some of the politics, economics, entrepreneurs and technologies involved in developing cars that ran on renewable-energy sources, up until the book’s writing.

Ghosts from the Nursery

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The Book of the Week is “Ghosts from the Nursery, Tracing the Roots of Violence” by Robin Karr-Morse and Meredith S. Wiley, published in 1997. The authors cited scientific studies to support their assertions about the links between the increasingly younger ages at which Americans are committing increasingly more frequent horrific crimes, and the social and cultural trends that are driving this alarming revelation.

At the book’s writing, in the United States, criminal justice system spending was three times (!) the entire healthcare budget. The authors argued that the seeds of criminality in humans are planted in the womb rather than in early childhood, as previously thought.

Environmental factors, such as a future mother’s or father’s consumption or inhalation of toxic substances, alters the reproductive mechanisms in a fetus’ brain cells. If the fetus’ environment is neglectful, chaotic or hostile– people are raucous, or physically abusing the mother-to-be– it stands to reason that the child might have behavioral problems later on. These problems could range from hyperactivity, impulsivity, attention deficits and learning disabilities to criminality.

The range and extent of damage done varies with the time frame in which the abuses occur. It has been found that any amount of alcohol drunk by a potential father or mother can adversely affect: spermatozoa and ova weeks before conception, the zygote, embryo, fetus and then the child’s health thereafter. Maximum visual damage is done to the brain of a fetus, when the abuses occur during the limited time, for instance, in which the neural connection from the retina to the visual cortex is made. Language skills develop or fail to develop, similarly.

The opposite is true, too: a nurturing environment will maximize benefits for the child (even in the womb!) when parents’ soothing or happy voices are heard by the fetus during his or her audiological development. After emergence from the womb, the baby can recognize his or her mother’s, father’s or others’ voices. Preverbal memory (an emotional vibe emitted by parents and others– a mood felt by the fetus and then infant and then child) stays with everyone through their entire lives. Parents have been shown to display the same behaviors their parents did with their own babies and children.

The authors mentioned several European studies that showed the incidences of juvenile criminality and suicide increased with an increase in unwanted pregnancies. That’s obviously a can of worms. But, since reams and reams of data have been collected from decades and decades of sociological, psychological, medical and legal studies worldwide, perhaps a multi-pronged approach applied locally would help– instead of commissioning more, additional expensive studies for the purposes of procrastination and patronage.

HOWEVER, one particularly rich vein of data on how to invite failure of the multi-pronged approach at the federal level of poverty-fighting (and on a related topic, crime-prevention), can be found in the administration archives of the late president Lyndon B. Johnson. A 20/20 hindsight look at the enduring actions he did take, are unfairly omitted from the history books that show an anti-liberal bias. His administration saw the start of Medicare and Medicaid and the passing of landmark civil rights legislation. BUT, these great accomplishments were overshadowed by conspiracy theories that he plotted the assassination of JFK and of course, his role in a needless war.

Johnson had grand plans to eliminate poverty at home, but shortly after he came to power, he decided to send Americans abroad to fight a war that led to countless deaths and ruined lives. And continued to rationalize why it needed to continue. Johnson’s anti-poverty programs weren’t given sufficient time to succeed because they became starved for funds.

That is why this country has regressed on the social-programs front: Every American president has sold his soul to the MILITARY [Currently, that military is fighting a war at the Mexican border instead of overseas; a future post of this blog will elaborate on this].

The only president fully justified in diverting significant taxpayer monies from improving conditions at home, toward fighting a war, was FDR. Since WWII, alpha males with hubris syndrome have been funding military actions whose long-term costs outweigh the benefits.

As a final insult that indicated that Johnson had major control issues, was the fact that he cruelly teased his own Democratic party by withdrawing from a 1968 reelection bid at the last minute, leaving the field to a few other candidates, and uncertainty in his wake. He also gave his political opponents a golden invitation to smear him in so many ways.

Granted, there are countless other vicissitudes of history that come into play with any president’s actions, but as is well known, campaign-finance regulation in America has become horribly eviscerated in recent decades, so the increase in financial influence of special-interest groups other than the military, has also played a role in this nation’s shifting priorities.

Be that as it may, the United States’ practices fly in the face of reason by bringing in a “pound of cure” (after the fact!) via a complicated, expensive bunch of bloated, bureaucratic government services (special-education, welfare, foster care, criminal justice, etc.). Instead of an “ounce of prevention.” One specific program has been found to be the most effective solution thus far in preventing crime in the long run: infant home-visitation programs, because the problems are dealt with early! This was the conclusion of a criminology team who submitted a report to the U.S. Congress in April 1997.

Clearly, different levels of government can implement more of a combination of social programs and legislation in order of what works best pursuant to all those scientific studies (preferably longitudinal ones), regardless of costs, limited by whatever the budget will reasonably bear; instead of going the easy, greedy, or power-hungry, politically expedient (and fraught military) route.

A grass-roots movement would have to hold officials’ feet to the fire on that– perhaps appealing to their egos by giving them a legacy via a footnote in the history books crediting them for getting it done. This, while keeping political patronage to a minimum (It used to be called “honest graft” but has reached excessive levels in certain regions; time will tell whether upcoming elections oust the “Tammany Hall/Boss Tweed” contingents.).

So, for instance, a hypothetical mandate for a large, diversely-populated city might consist of:

First, an infant home-visitation program;

Second, no-charge universal pre-kindergarten program;

Third, stricter background checks and bans on specific firearms and loophole-closing;

Fourth, a community-policing program (that does not involve military hardware) like those mentioned in this blog’s posts, “L.A. Justice” and “Riverkeepers”; and

Fifth, imposing and enforcing a legal maximum to class sizes in early-childhood education.

If additional funding is found (for whatever reasons), there could be other kinds of education programs that deal with issues such as: teen pregnancy, sex education, contraception, substance abuse prevention (all possibly as a part of the high school health-class curriculum), parenting classes, family planning, welfare-to-work, at-risk youth centers, and job training– again, prioritized from the most to the least effective outcomes.

Anyway, read the book to learn much more about research results on this topic, and the authors’ suggestions on crime prevention via focusing on ways to improve outcomes in connection with pregnancy and child care.

Code Name Ginger

[Please note: The word “Featured” on the left side above was NOT inserted by this blogger, but apparently was inserted by WordPress, and it cannot be removed. NO post in this blog is sponsored.]

“Now he was inventing a new story, in which I never told him that I was writing a book and in which he controlled anything I wrote.” Sounds familiar. “I” was Steve Kemper, the author of this book, and “he” was Dean Kamen, who became an amnesiac whenever it was convenient.

The Book of the Week is “Code Name Ginger, The Story Behind SEGWAY and Dean Kamen’s Quest to Invent a New World” by Steve Kemper, published in 2003.

Born in 1951 in Rockville Centre on Long Island, Dean Kamen is a spell-binding genius entrepreneur with some social blind spots. Nevertheless, he had a well-founded fear that “…scientific illiteracy would wreck the country’s economy, lifestyle and future.”

Anyway, by the time he graduated high school, he had become wealthy building cool audio-visual lighting systems that synchronized multiple slide projectors for rock bands and friends and family. By age 31, he was a multi-millionaire, after producing patented breakthrough medical products, horrifying other alpha males– ones who held graduate business degrees– with his drastic plans.

In the early 1990’s, some of Kamen’s company-employees began working on his vision for a new product– a wheelchair that adjusted the way a human being would, to different situations such as curbs and stairs. He was extremely possessive of his product, which was his heart and soul. He wouldn’t grant investors more than ten percent financial interest in the product. Ever.

In 1999, the creators planned to launch the new product, code-named “Ginger” early in the second quarter of 2001, and projected the construction of cookie-cutter factories on different continents that would build two million machines in ten years. However, Dean’s fellow employees felt he didn’t understand that high-volume manufacturing for a product like Ginger required hundreds of employees, a dozen loading docks, fleets of tractor-trailers, etc.

Kamen also reeked of overconfidence, even when presented with ample evidence that disproved his claims. In the late 1990’s, there was already so much competition from other products in the forms of various scooters and folding bikes. At a December 2000 meeting of investors, Steve Jobs told him that U.S. automakers would lobby against Ginger and the automakers would win.

Kamen’s ace in the hole was that he had friendly contact with nearly all of George W. Bush’s cabinet in early 2001. They had the power to grease the wheels of commerce in his favor.

Read the book to learn how the product turned into a toy for the rich but made mobility fun, and the personalities that shaped its evolution.

Uranium

The Book of the Week is “Uranium, War, Energy, and the Rock That Shaped the World” by Tom Zoellner, published in 2009.

Now, as is well known, one element crucial for making an atomic bomb via the least difficult method, is uranium. It is radioactive– carcinogenic to humans. Without human intervention, an entire sample of it takes billions of years (yes, really, depending on the isotope) to break down into one substance after another, including thirteen heavy metals; ultimately lead.

In the early 1940’s, “The United States military moved quickly to squelch all news of radioactivity. There were worries in the Pentagon that the bomb would be compared to German mustard gas in WWI or other types of wartime atrocities.” Radiation sickness and cancer killed an estimated thirty thousand people in addition to the seventy thousand who perished instantly by the atomic bomb at Hiroshima in August 1945.

In the late 1940’s, radium– an element that helps make a nuclear weapon– was found to be harmful to humans. The (federal) Atomic Energy Commission gave regulatory responsibilities of health and safety to state agencies in Colorado, Arizona and Utah, making the excuse that private mining businesses were outside its jurisdiction. Of course, the states were understaffed and underfunded in regulating radium.

Nevertheless, the radium rush became a government-directed priority because it was a matter of national security. By the 1960’s, the greed was petering out, and Navajo country (in northern Arizona, and small regions of Utah and New Mexico) was a cancer cluster comprised of an eyesore of about thirteen hundred abandoned mines laid waste with radon gas. That was one aspect of the nuclear age. Another was that building fallout-shelters became trendy. The Kennedy family built one at their estate in Palm Beach, Florida.

In the mid-1950’s the “Atoms For Peace” program begun by president Dwight Eisenhower supplied nuclear reactors to Bangladesh, Algeria, Colombia, Jamaica, Ghana, Peru, Syria, Pakistan, Turkey, and Belgian Congo for the purpose of deterring the said countries’ enemies from using nuclear weapons against them.

In 1988, the United States supplied Iran with a five megawatt research reactor; China supplied uranium ore, and South Africa, a block of uranium and some plutonium. The Pakistani A.Q. Khan was hired as a scientific consultant.

Since 1993, the Atomic Energy Commission was supposed to have recorded incidents in which different forms of uranium (raw ore, yellowcake, hexafluoride, metal oxide, ceramic pellets, and fuel rod assemblies) have gone missing. Incident reportage works on the honor system. Unsurprisingly, the system hasn’t worked because the substance has a very complex, global black-market. Even so, the biggest hurdle to building a nuclear weapon is obtaining uranium in its highly enriched form. Then one must employ people with weapons-design and explosives expertise. Hiding the project (which in part, can be accomplished via a lead sleeve on the finished product– that would fool a radiation detector) might pose additional difficulties. It would cost a total of a few million (U.S.) dollars besides.

In the single-digit 2000’s, the author personally visited the country of Niger to see a uranium town for himself; a life-threatening trip. For, bandits or terrorists (likely of the Tuareg tribe who believe uranium mining has fostered inequality that adversely affects them economically, tribally and health-wise) appeared in front of his bus en route (a not uncommon occurrence). The bus driver was wise to the situation and drove away from the scene to a rural village with electricity, thanks to a nearby French power plant. The two main exports of Niger are uranium and onions. But the nation is still largely agricultural.

Read the book to learn much more about uranium in connection with: its sourcing in Australia, U.S. strategic interests in Soviet Georgia, Yemen’s goals, a Sierra Club legal fight, Vancouver’s ill-gotten gains, etc.

Betrayers of the Truth

The Book of the Week is “Betrayers of the Truth– Fraud and Deceit in the Halls of Science” by William Broad & Nicholas Wade, published in 1982.

Scientists have always emphasized that their ilk are “a rational, self-correcting, self-policing community of scholars.” They consider themselves to be superior because they believe their field of work is more “factual” and requires more education than other kinds of work. Yet even they behave in unethical ways– likely in the same proportion as the population at large– because they too, possess the unattractive traits of human nature.

The authors remarked that even some of the most famous scientists in history (such as Ptolemy, Galileo and Netwon to name just three) have fudged data, plagiarized, or lied about performing experiments they didn’t actually perform. The scientists wanted the data to fit their theories; they were lazy, greedy or glory-seeking, or a combination of those.

The authors lamented that the scientific community’s culture encouraged an atmosphere in which fraud could be perpetrated and perpetuated easily, and not be discovered for decades. In fact, the authors provided numerous, specific examples in which fraud flourished.

The reason scandals of misrepresentation in science are so dangerous is that they have a ripple effect on so many other areas of life– testing of food and drugs, matters of class and race, immigration, and education– to name a few.

At the book’s writing, publishing articles about their new discoveries in professional journals was the major way scientists furthered their careers. There was an avalanche of publications. The obscure publications had a decided lack of fact-checking of article-contents.

In 1962, and again in 1973, researchers sought to test honesty in the community. The results were less than stellar. “Fewer than one in four scientists were willing to provide raw data on request, without self-serving conditions, and nearly half of the studies analyzed had gross errors in their statistics alone.”

As is well known, science in academia has a hierarchical structure. The elitism feeds on itself. Big-name scientists at prestigious universities are necessarily trusted more for integrity than nobodies are, so their articles and grant applications are less carefully vetted, and they therefore get more prizes, editorships, and lectureships. Their reputations as “experts” become even more widespread.

However, history is rife with stories of nobodies who fought fiercely for recognition because they knew their methods or theories were superior. And often late in their careers, or posthumously, their contributions were recognized. Such greats included, but were certainly not limited to: George Ohm, Gregor Mendel, Alfred Wegener and Sister Kenny.

Sadly, it seems as though, now more than ever, many “science” shows on once-reputable cable-TV channels purport to educate viewers, but at best, convey trivia put out by profiteers, propagandists and attention whores.

Another indication of ignorance of science was highlighted during the coronavirus pandemic in America. Government at all levels ordered masking of all individuals while its propaganda machine squelched the fact that:

covering one’s face with non-sterile fabric and breathing in one’s own toxic exhalations more likely propagates illness rather than minimizes the spread of it!

According to NIH News, “Your mouth is home to about 700 species of germs, like bacteria, fungus, and more.”

Read the book to learn a wealth of additional details on how the scientific community takes care of its own, and other reasons dishonesty in science is actually more prevalent than it appears to be.

Appointment at the Ends of the World

The Book of the Week is “Appointment at the Ends of the World, Memoirs of A Wildlife Veterinarian” by William B. Karesh, published in 1999.

The American author traveled to exotic locales to participate in conservation projects for the Wildlife Conservation Society and other international aid organizations, which manage and study animals and their habitats and resources in tens of countries. He got special permission from governments to bring a vast quantity of supplies and equipment to jungles, savannas, forests, etc.

The author spent part of the year at the Bronx Zoo. In 1995, he flew to northeastern Zaire to treat an infection in one okapi, and was driven hours to enter a safari park to study white rhinos. His luggage weighed 220 pounds. It was full of sampling supplies (tubes, racks, pipettes, towels, etc.), drugs for the animals, immobilization / capture equipment (like oxygen and carbon dioxide tanks, cartridges and numerous accessories), animal-handling and marking equipment (clips, cards, etc.), books, cords, converters and other miscellaneous items, and camping gear. Not to mention, clothing.

In Bolivia, the author performed various tests to measure the amount of environmental contaminants in the bodies of wild caimans because they live thirty to forty years. Examining the reptiles at intervals can indicate changes in their aquatic habitats.

In Cameroon, the author encountered shenanigans. For, he had to hire local guides; the leader (a native Nigerian) was fluent in the English language, and allegedly skilled at finding forest-elephants. The leader led the group on a “wild-goose chase” for weeks. When the group finally got close enough to one animal at which to shoot a radio-transmitter dart and a tranquilizer-dart, the leader missed twice shooting the former dart. The adrenaline was pumping in the people too, because the territorial elephants can crush humans to death.

The author conceded that he was doing an extremely controversial job. He and his employers threw vast amounts of resources at animals to save their lives or help them survive. He behaved like a Darwin-award candidate at times, and at other times, ironically, over the long run– made conditions worse for his charges. Ecotourism, too, whose goal is profiteering (rather than sincere concern for endangered species)– has taken its toll on disrupting animal habitats.

The phrase “white savior complex” could now be applied to the way wealthy people condescendingly think that saving a few individuals will solve the extremely complex problems of survival faced by all of the earth’s organisms. It is fair to say that in recent decades, money has actually corrupted global efforts to save lots of them.

To boot, the decades wasted searching for aliens and Bigfoot have just muddied the waters more. Incidentally, as is well known, on the TV show Star Trek, the aliens always speak perfect American English. Lastly, people who bother animals to get attention are still a “thing” on the idiot box, despite Steve Irwin’s cautionary tale. Anyway, read the book to learn a wealth of additional details on the author’s career, and how it shaped his lifestyle.

Surviving the Extremes – BONUS POST

The Bonus Book of the Week is “Surviving the Extremes, A Doctor’s Journey to the Limits of Human Endurance” by Kenneth Kamler, M.D., published in 2004.

The author, a medical doctor, described people’s experiences: in the Amazon jungle, while deep-sea diving, on Mount Everest, in the desert, on the high seas, and in a spaceship. The adventurers were subjected to life-threatening conditions at every turn (by choice— they were Darwin award candidates), but possessed expertise and technology that bettered their chances of survival. Their local-area employees possessed the physical characteristics advantageous for survival because those employees had become adapted to the harsh conditions over the course of generations. Some people did die, though. However, the author failed to specify the time-frames of the above scenarios. The introduction of new technologies, and discoveries have probably prevented or mitigated some of those kinds of disasters, since the book’s writing.

One point the author made, concerns the relationship between the human brain and society. A society can regress when an influential leader in a position of power breaks a taboo. His followers will copy him and rationalize away the sin. It then becomes easier to break additional taboos. Eventually, fairness and morality go out the window, because human brains actually adopt a more primitive way of thinking.

The cerebral cortex of the brain guides the ethics of behavior, but the amygdala takes over when tempers flare, and impulse control decreases. If the amygdalas of a significant portion of the population are activated via vicious political rumors, such as:

  • Biden’s going to pack the U.S. Supreme Court!
  • Medicare’s going to be privatized!
  • Biden’s senile and Harris is going to take over the country!
  • The Republicans are going to win back the House in the 2022 midterm elections!

the nation’s behavior regresses. Enough said.

Anyway, read the book to learn a lot about the roles physiology, biochemical processes, psychology and man-made resources play in survival when humans are present in places that tax their limitations.

Pharma

The Book of the Week is “Pharma– Greed, Lies, and the Poisoning of America” by Gerald Posner, published in 2020.

In 2016, the “superbug” Enterobacteriaceae turned out to be resistant to 26 different antibiotics. About half of patients who contract it, die. There are a bunch of other similar bacteria in the world. The author warned that in the future, a bacterial pandemic was on the way, for which there would be no antibiotic cure. Apparently, there can be a viral pandemic, too– one that cannot be treated with antibiotics at all.

For, antibiotics kill only bacteria, if that. Yet, in the United States, for decades, antibiotics have been prescribed to treat (mild!) viral illnesses. That is one major reason that superbugs have become a trend. And there has been an epidemic of diabetes type II. And many other adverse consequences.

Anyway, the author recounted the history of big-name drug companies, which began selling morphine to soldiers during the American Civil War. In the second half of the 1800’s, Pfizer, Squibb, Wyeth, Parke-Davis, Eli Lilly, and Burroughs-Wellcome began mostly as family proprietorships that sold highly addictive, unregulated drugs. Bayer produced heroin in 1898. The twentieth century saw Merck put cocaine in its products; other companies jumped on the cocaine bandwagon.

In 1904, the head of the United States government’s Bureau of Chemistry, Harvey Wiley, was concerned about contaminants in the nation’s food supply. Consumers were being sickened by chemicals that were supposed to retard spoilage or enhance the appeal of foods. They included, but were far from limited to: borax, salicylic acid, formaldehyde, benzoate, copper sulfate and sulfites. Trendy patent medicines were also doing harm to consumers. The word “patent” gave the impression of approval or regulation of some kind, but actually meant nothing.

Through the first third of the twentieth century, the government continued categorizing, monitoring and taxing drugs, but the pharmaceutical companies continued using trade groups and legal strategists to protect their profits. The 1930’s saw the big drug companies start research laboratories. Finally in 1938, the government established the Food and Drug Administration, and began to require extensive product-testing and labeling, and factory inspections. That same year, the Wheeler-Lea Act prohibited false advertising of drugs, except for previously manufactured barbiturates and amphetamines.

After Pearl Harbor was attacked in December 1941, America sought to manufacture penicillin in volume. For, the newly introduced antibiotic would be very helpful to the war wounded. But the drug’s fermentation process required a rare ingredient. In spring 1942, one patient who had friends in high places was cured. That largely used up the penicillin supply in the entire country. Other kinds of antibiotics were produced in the next decade, but their profitability was hampered by the bureaucratic processes of patent applications and FDA approval applications.

In the late 1940’s, Arthur Sackler and his brothers founded a family drug-company dynasty. The author revealed excessive trivia from FBI files on them and other greedy characters whose tentacles pervaded all businesses that could help sell (translation: maximize profits of) the family’s healthcare goods and services. This meant consulting, advertising, publishing, charities, public relations, database services, etc. The parties failed to disclose countless conflicts of interest.

In the early 1950’s, drug companies successfully lobbied the U.S. Patent and Trademark Office to allow drugs with strikingly similar molecular structures to be deemed different so that they could be granted separate patents. A higher number of drugs could then be rushed to market sooner, and make the most money.

In 1952, farmers fed Pfizer’s antibiotics to their animals so that they grew bigger (both Pfizer and the animals). In the mid-1950’s, Pfizer, Lederle, Squibb, Bristol and Upjohn engaged in an illegal tetracycline price-fixing scheme. They reaped hundreds of millions of dollars in earnings. The FDA chief was in Sackler’s back pocket. So when violations came to light, the FTC and FDA gave the offenders a slap on the wrist. However, senator Estes Kefauver was a thorn in their side.

Kefauver led an investigation as to why America’s drug prices were so excessively high when compared with those in other nations. In fighting back, the drug industry smeared Kefauver as a liberal pinko, claiming he had designs on forcing socialized medicine on the United States. The nineteen drugmakers under the gun gave bogus excuses. The real reason is that America’s drug prices and patents are subjected to minimal or no regulation, unlike everywhere else.

In 1956, Americans were told they were stressed, but a wonder drug called “Miltown” would help calm them down. The mild tranquilizer became a best-seller, until it was counterfeited and appeared on the black market, and its adverse side effects gave it bad publicity. Oh, well.

Then in the 1960’s came the culture-changing birth control Pill, and Valium– also called “mother’s little helper” that was marketed as a weight-loss aid. The next game-changer was thalidomide. Kefauver used the worldwide backlash against this drug to push through some drug safety and effectiveness regulation in the United States in 1963. For a change. Even so, in 1972, when the U.S. Supreme Court confirmed certain regulatory powers conferred on the FDA, drugmakers merely sought additional markets for their products on other continents.

In 1976, there was a swine flu epidemic in America. Healthcare companies were reluctant to develop a vaccine for it, fearing an orgy of litigation from victims if any harm was done. So the government unwisely agreed to foot any legal bills. Sure enough, some vaccine recipients developed cases of Guillain Barre syndrome, and neurological complications. The (taxpayer-funded) Justice Department took the hit. Other parties piled on. “The CDC had exploited ‘Washington’s panic’ to ‘increase the size of its empire and multiply its budget.’ “

Moving on, the author told the whole sordid story of the “opioid crisis” in America. In a nutshell: in May 2002, Purdue Pharma, maker and unethical marketer of OxyContin, hired Rudy Giuliani’s firm to defend it against the firestorm from its host of illegal activities. The firm collected a $3 million fee per month. Purdue collected $30 million per week from OxyContin sales. To be fair, Purdue and the Sackler family were the poster-scapegoats of the crisis. Numerous other parties aided and abetted them: other pharmaceutical companies, doctors, FDA bureaucrats, and pain management “experts” and pharmacists. The far-reaching consequences have caused a lot of trouble for society as a whole in the areas of: increased healthcare costs, criminal justice, social services, drug rehabilitation services, lost productivity and earnings, etc.

Read the book to learn an additional wealth of details and the details of wealth of the healthcare industry’s evolution into a hegemonic legal behemoth / excessive profit center, in the form of a series of cautionary tales in various topic areas– drug advertising, blood donations, biotech, epidemics, pharmacy benefit managers– that wrought major good and bad (mostly bad) cultural and regulatory changes (including the Hatch-Waxman Act and the Orphan Drug Act); plus the family battles following the sudden death of Arthur Sackler.