Dr. Folkman’s War

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The Book of the Week is “Dr. Folkman’s War, Angiogenesis and the Struggle to Defeat Cancer” by Robert Cooke, published in 2001.

In the 1970’s, Judah Folkman was a competent surgeon and a very popular professor at Harvard Medical School, but his first love was medical research. He hypothesized about why and how a tumor grows. He inferred that blood vessels grow toward a tumor, but was unable to provide proof for a very long time. He was ostracized for having this radical idea, so he had difficulty attracting enthusiastic graduate students to assist him, and with getting funding for his research.

Traditionally, university medical studies in laboratories had been funded by government grants. Profiteering from patents and medical products resulting from research was considered sleazy in scientific circles. In 1974, Harvard broke the taboo and partnered with the large, profit-making organization called Monsanto.

Even after receiving generous funding, Dr. Folkman worked around the clock simply because making new medical discoveries requires months or years of blood, sweat and tears. The materials required to do experiments can be expensive, messy, odorous and pose unanticipated problems. For a while, Folkman’s lab was working with vast quantities of cow and shark meat (and other obscure, problematic materials) because the animals’ cartilage contains no blood vessels.

Even after the doctor’s studies yielded exciting breakthroughs, media articles influenced the medical community and the public in ways that were harmful to Folkman’s research operations. There were even accusations of fraud against him. It turned out that in his team’s haste to treat cancer patients, many errors were made. Time was of the essence, and procedures for organized data collection were lacking. Folkman wasn’t deliberately trying to deceive anyone.

Folkman was a rare bird in that he was quite altruistic with his time and talents. His patience and persistence allowed him to ignore his detractors and the naysayers (most of whom were jealous). He eventually acquired an area of expertise that not only spawned a new way of thinking about cancer treatment, but also led to treatments for other medical conditions, and whole new industries, including biotech. He also helped shatter a myth in cancer treatment. But this additional idea of Folkman’s still might not be fully accepted in oncology circles (due to GREED), even two decades after the writing of this book.

This is what he learned: The approach to cancer-drug delivery to a tumor of:

“low [dosage] and slow [buildup over the long-term]” was shown to be superior to

“might makes right” and come in with guns blazing; in the past, it was hoped that immediate, large doses would eliminate the tumor before metastasis, and before the patient died from the deaths of too many healthy cells that were also killed in the process.

In other words: The patient’s treatment should begin with a low drug dosage, and if that proves ineffective, increase the dosage gradually until it is effective. Folkman’s experiences with patients showed that that was the successful way to go, and he even saw a few miraculous cures.

Read the book to learn many more details on Folkman’s trials and tribulations and the reasons for them, and what transpired when he finally found vindication.

Ghosts from the Nursery

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The Book of the Week is “Ghosts from the Nursery, Tracing the Roots of Violence” by Robin Karr-Morse and Meredith S. Wiley, published in 1997. The authors cited scientific studies to support their assertions about the links between the increasingly younger ages at which Americans are committing increasingly more frequent horrific crimes, and the social and cultural trends that are driving this alarming revelation.

At the book’s writing, in the United States, criminal justice system spending was three times (!) the entire healthcare budget. The authors argued that the seeds of criminality in humans are planted in the womb rather than in early childhood, as previously thought.

Environmental factors, such as a future mother’s or father’s consumption or inhalation of toxic substances, alters the reproductive mechanisms in a fetus’ brain cells. If the fetus’ environment is neglectful, chaotic or hostile– people are raucous, or physically abusing the mother-to-be– it stands to reason that the child might have behavioral problems later on. These problems could range from hyperactivity, impulsivity, attention deficits and learning disabilities to criminality.

The range and extent of damage done varies with the time frame in which the abuses occur. It has been found that any amount of alcohol drunk by a potential father or mother can adversely affect: spermatozoa and ova weeks before conception, the zygote, embryo, fetus and then the child’s health thereafter. Maximum visual damage is done to the brain of a fetus, when the abuses occur during the limited time, for instance, in which the neural connection from the retina to the visual cortex is made. Language skills develop or fail to develop, similarly.

The opposite is true, too: a nurturing environment will maximize benefits for the child (even in the womb!) when parents’ soothing or happy voices are heard by the fetus during his or her audiological development. After emergence from the womb, the baby can recognize his or her mother’s, father’s or others’ voices. Preverbal memory (an emotional vibe emitted by parents and others– a mood felt by the fetus and then infant and then child) stays with everyone through their entire lives. Parents have been shown to display the same behaviors their parents did with their own babies and children.

The authors mentioned several European studies that showed the incidences of juvenile criminality and suicide increased with an increase in unwanted pregnancies. That’s obviously a can of worms. But, since reams and reams of data have been collected from decades and decades of sociological, psychological, medical and legal studies worldwide, perhaps a multi-pronged approach applied locally would help– instead of commissioning more, additional expensive studies for the purposes of procrastination and patronage.

HOWEVER, one particularly rich vein of data on how to invite failure of the multi-pronged approach at the federal level of poverty-fighting (and on a related topic, crime-prevention), can be found in the administration archives of the late president Lyndon B. Johnson. A 20/20 hindsight look at the enduring actions he did take, are unfairly omitted from the history books that show an anti-liberal bias. His administration saw the start of Medicare and Medicaid and the passing of landmark civil rights legislation. BUT, these great accomplishments were overshadowed by conspiracy theories that he plotted the assassination of JFK and of course, his role in a needless war.

Johnson had grand plans to eliminate poverty at home, but shortly after he came to power, he decided to send Americans abroad to fight a war that led to countless deaths and ruined lives. And continued to rationalize why it needed to continue. Johnson’s anti-poverty programs weren’t given sufficient time to succeed because they became starved for funds.

That is why this country has regressed on the social-programs front: Every American president has sold his soul to the MILITARY [Currently, that military is fighting a war at the Mexican border instead of overseas; a future post of this blog will elaborate on this].

The only president fully justified in diverting significant taxpayer monies from improving conditions at home, toward fighting a war, was FDR. Since WWII, alpha males with hubris syndrome have been funding military actions whose long-term costs outweigh the benefits.

As a final insult that indicated that Johnson had major control issues, was the fact that he cruelly teased his own Democratic party by withdrawing from a 1968 reelection bid at the last minute, leaving the field to a few other candidates, and uncertainty in his wake. He also gave his political opponents a golden invitation to smear him in so many ways.

Granted, there are countless other vicissitudes of history that come into play with any president’s actions, but as is well known, campaign-finance regulation in America has become horribly eviscerated in recent decades, so the increase in financial influence of special-interest groups other than the military, has also played a role in this nation’s shifting priorities.

Be that as it may, the United States’ practices fly in the face of reason by bringing in a “pound of cure” (after the fact!) via a complicated, expensive bunch of bloated, bureaucratic government services (special-education, welfare, foster care, criminal justice, etc.). Instead of an “ounce of prevention.” One specific program has been found to be the most effective solution thus far in preventing crime in the long run: infant home-visitation programs, because the problems are dealt with early! This was the conclusion of a criminology team who submitted a report to the U.S. Congress in April 1997.

Clearly, different levels of government can implement more of a combination of social programs and legislation in order of what works best pursuant to all those scientific studies (preferably longitudinal ones), regardless of costs, limited by whatever the budget will reasonably bear; instead of going the easy, greedy, or power-hungry, politically expedient (and fraught military) route.

A grass-roots movement would have to hold officials’ feet to the fire on that– perhaps appealing to their egos by giving them a legacy via a footnote in the history books crediting them for getting it done. This, while keeping political patronage to a minimum (It used to be called “honest graft” but has reached excessive levels in certain regions; time will tell whether upcoming elections oust the “Tammany Hall/Boss Tweed” contingents.).

So, for instance, a hypothetical mandate for a large, diversely-populated city might consist of:

First, an infant home-visitation program;

Second, no-charge universal pre-kindergarten program;

Third, stricter background checks and bans on specific firearms and loophole-closing;

Fourth, a community-policing program (that does not involve military hardware) like those mentioned in this blog’s posts, “L.A. Justice” and “Riverkeepers”; and

Fifth, imposing and enforcing a legal maximum to class sizes in early-childhood education.

If additional funding is found (for whatever reasons), there could be other kinds of education programs that deal with issues such as: teen pregnancy, sex education, contraception, substance abuse prevention (all possibly as a part of the high school health-class curriculum), parenting classes, family planning, welfare-to-work, at-risk youth centers, and job training– again, prioritized from the most to the least effective outcomes.

Anyway, read the book to learn much more about research results on this topic, and the authors’ suggestions on crime prevention via focusing on ways to improve outcomes in connection with pregnancy and child care.

A Storm Too Soon – BONUS POST

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The Bonus Book of the Week is “A Storm Too Soon, A True Story of Disaster, Survival, and an Incredible Rescue” by Michael J. Touglas, published in 2013.

This suspenseful story recounted the abbreviated May 2007 voyage of three Darwin-Award candidates who began to sail from the northern coast of Florida across the Atlantic Ocean to Gibraltar. Hazards included, among others– sudden, unexpected storms, spilled contents of container ships and inaccurate maps (due to recently washed-away sandbars).

“Every screw, rivet, line, seam, porthole, and the rest of what makes up a sailboat has to hold under the assault of the seas.” Unfortunately, the entire contents of the captain and crew’s 55-foot sailboat had a difficult time staying afloat, when an unseasonable squall broke a window that immediately let in 80-foot-high waves and 80-knot wind gusts. Miraculously, the life raft stayed intact. However, the various tools they had for sending distress signals to the Coast Guard were less than ideal, for different reasons.

Predictably, the three men were at high risk for drowning, harm from sharks, dehydration and hypothermia. In a case like this, rescuers who approach them via C-130 plane and helicopter, risk their lives in numerous ways. First, the plane searches an area equivalent to the needle-in-a-haystack cliche.

Read the book to learn many more details, and the fate of the participants in the above story.

The Nation Got Run Over – BONUS POST

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THE NATION GOT RUN OVER BY A PLAGUE HERE

sung to the tune of “Grandma Got Run Over By A Reindeer” with apologies to Randy Brooks, Elmo (and Patsy) Trigg, and whichever other rights holders this may concern.

The nation got run over by a plague here
from years of White House gyrations election eve.
You can say political donors play Santa
and voters have no CLUE what to believe.

Some are drinking too much Kool-Aid
and others abuse their power so.
Still others scream for medication.
The hostility of some has reached a new low.

When they confined us in 2020,
they began a dangerous age.
We resented the intrusion,
and our State is such
we have yet to turn the page.

The nation got run over by a plague here
from years of White House gyrations election eve.
You can say political donors play Santa
and voters have no CLUE what to believe.

It’s less than A year until midterms.
Our leaders’ messaging’s a joke.
See no masks on players of football
while tests and shots are FORCED on powerless folk.

It’s not nice to fool the people.
All the nation’s mad as hell,
and we just can’t help but wonder,
how much more must we endure before we’re well?

The nation got run over by a plague here
from years of White House gyrations election eve.
You can say political donors play Santa
and voters have no CLUE what to believe.

Soon the voters get to DEcide
whose heads are going to roll.
All those blue and red state mandates
are going to change pursuant to every political poll.

I urge all my fellow Americans:
you need to follow politics and vote.
The government has taken license
to curb our freedoms
and make their enemies the scapegoat.

The nation got run over by a plague here
from years of White House gyrations election eve.
You can say political donors play Santa
and voters have no CLUE what to believe.

The nation got run over by a plague here
from years of White House gyrations election eve.
You can say political donors play Santa
and voters have no CLUE what to believe.

Betrayers of the Truth

The Book of the Week is “Betrayers of the Truth– Fraud and Deceit in the Halls of Science” by William Broad & Nicholas Wade, published in 1982.

Scientists have always emphasized that their ilk are “a rational, self-correcting, self-policing community of scholars.” They consider themselves to be superior because they believe their field of work is more “factual” and requires more education than other kinds of work. Yet even they behave in unethical ways– likely in the same proportion as the population at large– because they too, possess the unattractive traits of human nature.

The authors remarked that even some of the most famous scientists in history (such as Ptolemy, Galileo and Netwon to name just three) have fudged data, plagiarized, or lied about performing experiments they didn’t actually perform. The scientists wanted the data to fit their theories; they were lazy, greedy or glory-seeking, or a combination of those.

The authors lamented that the scientific community’s culture encouraged an atmosphere in which fraud could be perpetrated and perpetuated easily, and not be discovered for decades. In fact, the authors provided numerous, specific examples in which fraud flourished.

The reason scandals of misrepresentation in science are so dangerous is that they have a ripple effect on so many other areas of life– testing of food and drugs, matters of class and race, immigration, and education– to name a few.

At the book’s writing, publishing articles about their new discoveries in professional journals was the major way scientists furthered their careers. There was an avalanche of publications. The obscure publications had a decided lack of fact-checking of article-contents.

In 1962, and again in 1973, researchers sought to test honesty in the community. The results were less than stellar. “Fewer than one in four scientists were willing to provide raw data on request, without self-serving conditions, and nearly half of the studies analyzed had gross errors in their statistics alone.”

As is well known, science in academia has a hierarchical structure. The elitism feeds on itself. Big-name scientists at prestigious universities are necessarily trusted more for integrity than nobodies are, so their articles and grant applications are less carefully vetted, and they therefore get more prizes, editorships, and lectureships. Their reputations as “experts” become even more widespread.

However, history is rife with stories of nobodies who fought fiercely for recognition because they knew their methods or theories were superior. And often late in their careers, or posthumously, their contributions were recognized. Such greats included, but were certainly not limited to: George Ohm, Gregor Mendel, Alfred Wegener and Sister Kenny.

Sadly, it seems as though, now more than ever, many “science” shows on once-reputable cable-TV channels purport to educate viewers, but at best, convey trivia put out by profiteers, propagandists and attention whores.

Another indication of ignorance of science was highlighted during the coronavirus pandemic in America. Government at all levels ordered masking of all individuals while its propaganda machine squelched the fact that:

covering one’s face with non-sterile fabric and breathing in one’s own toxic exhalations more likely propagates illness rather than minimizes the spread of it!

According to NIH News, “Your mouth is home to about 700 species of germs, like bacteria, fungus, and more.”

Read the book to learn a wealth of additional details on how the scientific community takes care of its own, and other reasons dishonesty in science is actually more prevalent than it appears to be.

Surviving the Extremes – BONUS POST

The Bonus Book of the Week is “Surviving the Extremes, A Doctor’s Journey to the Limits of Human Endurance” by Kenneth Kamler, M.D., published in 2004.

The author, a medical doctor, described people’s experiences: in the Amazon jungle, while deep-sea diving, on Mount Everest, in the desert, on the high seas, and in a spaceship. The adventurers were subjected to life-threatening conditions at every turn (by choice— they were Darwin award candidates), but possessed expertise and technology that bettered their chances of survival. Their local-area employees possessed the physical characteristics advantageous for survival because those employees had become adapted to the harsh conditions over the course of generations. Some people did die, though. However, the author failed to specify the time-frames of the above scenarios. The introduction of new technologies, and discoveries have probably prevented or mitigated some of those kinds of disasters, since the book’s writing.

One point the author made, concerns the relationship between the human brain and society. A society can regress when an influential leader in a position of power breaks a taboo. His followers will copy him and rationalize away the sin. It then becomes easier to break additional taboos. Eventually, fairness and morality go out the window, because human brains actually adopt a more primitive way of thinking.

The cerebral cortex of the brain guides the ethics of behavior, but the amygdala takes over when tempers flare, and impulse control decreases. If the amygdalas of a significant portion of the population are activated via vicious political rumors, such as:

  • Biden’s going to pack the U.S. Supreme Court!
  • Medicare’s going to be privatized!
  • Biden’s senile and Harris is going to take over the country!
  • The Republicans are going to win back the House in the 2022 midterm elections!

the nation’s behavior regresses. Enough said.

Anyway, read the book to learn a lot about the roles physiology, biochemical processes, psychology and man-made resources play in survival when humans are present in places that tax their limitations.