Pharma

The Book of the Week is “Pharma– Greed, Lies, and the Poisoning of America” by Gerald Posner, published in 2020.

In 2016, the “superbug” Enterobacteriaceae turned out to be resistant to 26 different antibiotics. About half of patients who contract it, die. There are a bunch of other similar bacteria in the world. The author warned that in the future, a bacterial pandemic was on the way, for which there would be no antibiotic cure. Apparently, there can be a viral pandemic, too– one that cannot be treated with antibiotics at all.

For, antibiotics kill only bacteria, if that. Yet, in the United States, for decades, antibiotics have been prescribed to treat (mild!) viral illnesses. That is one major reason that superbugs have become a trend. And there has been an epidemic of diabetes type II. And many other adverse consequences.

Anyway, the author recounted the history of big-name drug companies, which began selling morphine to soldiers during the American Civil War. In the second half of the 1800’s, Pfizer, Squibb, Wyeth, Parke-Davis, Eli Lilly, and Burroughs-Wellcome began mostly as family proprietorships that sold highly addictive, unregulated drugs. Bayer produced heroin in 1898. The twentieth century saw Merck put cocaine in its products; other companies jumped on the cocaine bandwagon.

In 1904, the head of the United States government’s Bureau of Chemistry, Harvey Wiley, was concerned about contaminants in the nation’s food supply. Consumers were being sickened by chemicals that were supposed to retard spoilage or enhance the appeal of foods. They included, but were far from limited to: borax, salicylic acid, formaldehyde, benzoate, copper sulfate and sulfites. Trendy patent medicines were also doing harm to consumers. The word “patent” gave the impression of approval or regulation of some kind, but actually meant nothing.

Through the first third of the twentieth century, the government continued categorizing, monitoring and taxing drugs, but the pharmaceutical companies continued using trade groups and legal strategists to protect their profits. The 1930’s saw the big drug companies start research laboratories. Finally in 1938, the government established the Food and Drug Administration, and began to require extensive product-testing and labeling, and factory inspections. That same year, the Wheeler-Lea Act prohibited false advertising of drugs, except for previously manufactured barbiturates and amphetamines.

After Pearl Harbor was attacked in December 1941, America sought to manufacture penicillin in volume. For, the newly introduced antibiotic would be very helpful to the war wounded. But the drug’s fermentation process required a rare ingredient. In spring 1942, one patient who had friends in high places was cured. That largely used up the penicillin supply in the entire country. Other kinds of antibiotics were produced in the next decade, but their profitability was hampered by the bureaucratic processes of patent applications and FDA approval applications.

In the late 1940’s, Arthur Sackler and his brothers founded a family drug-company dynasty. The author revealed excessive trivia from FBI files on them and other greedy characters whose tentacles pervaded all businesses that could help sell (translation: maximize profits of) the family’s healthcare goods and services. This meant consulting, advertising, publishing, charities, public relations, database services, etc. The parties failed to disclose countless conflicts of interest.

In the early 1950’s, drug companies successfully lobbied the U.S. Patent and Trademark Office to allow drugs with strikingly similar molecular structures to be deemed different so that they could be granted separate patents. A higher number of drugs could then be rushed to market sooner, and make the most money.

In 1952, farmers fed Pfizer’s antibiotics to their animals so that they grew bigger (both Pfizer and the animals). In the mid-1950’s, Pfizer, Lederle, Squibb, Bristol and Upjohn engaged in an illegal tetracycline price-fixing scheme. They reaped hundreds of millions of dollars in earnings. The FDA chief was in Sackler’s back pocket. So when violations came to light, the FTC and FDA gave the offenders a slap on the wrist. However, senator Estes Kefauver was a thorn in their side.

Kefauver led an investigation as to why America’s drug prices were so excessively high when compared with those in other nations. In fighting back, the drug industry smeared Kefauver as a liberal pinko, claiming he had designs on forcing socialized medicine on the United States. The nineteen drugmakers under the gun gave bogus excuses. The real reason is that America’s drug prices and patents are subjected to minimal or no regulation, unlike everywhere else.

In 1956, Americans were told they were stressed, but a wonder drug called “Miltown” would help calm them down. The mild tranquilizer became a best-seller, until it was counterfeited and appeared on the black market, and its adverse side effects gave it bad publicity. Oh, well.

Then in the 1960’s came the culture-changing birth control Pill, and Valium– also called “mother’s little helper” that was marketed as a weight-loss aid. The next game-changer was thalidomide. Kefauver used the worldwide backlash against this drug to push through some drug safety and effectiveness regulation in the United States in 1963. For a change. Even so, in 1972, when the U.S. Supreme Court confirmed certain regulatory powers conferred on the FDA, drugmakers merely sought additional markets for their products on other continents.

In 1976, there was a swine flu epidemic in America. Healthcare companies were reluctant to develop a vaccine for it, fearing an orgy of litigation from victims if any harm was done. So the government unwisely agreed to foot any legal bills. Sure enough, some vaccine recipients developed cases of Guillain Barre syndrome, and neurological complications. The (taxpayer-funded) Justice Department took the hit. Other parties piled on. “The CDC had exploited ‘Washington’s panic’ to ‘increase the size of its empire and multiply its budget.’ “

Moving on, the author told the whole sordid story of the “opioid crisis” in America. In a nutshell: in May 2002, Purdue Pharma, maker and unethical marketer of OxyContin, hired Rudy Giuliani’s firm to defend it against the firestorm from its host of illegal activities. The firm collected a $3 million fee per month. Purdue collected $30 million per week from OxyContin sales. To be fair, Purdue and the Sackler family were the poster-scapegoats of the crisis. Numerous other parties aided and abetted them: other pharmaceutical companies, doctors, FDA bureaucrats, and pain management “experts” and pharmacists. The far-reaching consequences have caused a lot of trouble for society as a whole in the areas of: increased healthcare costs, criminal justice, social services, drug rehabilitation services, lost productivity and earnings, etc.

Read the book to learn an additional wealth of details and the details of wealth of the healthcare industry’s evolution into a hegemonic legal behemoth / excessive profit center, in the form of a series of cautionary tales in various topic areas– drug advertising, blood donations, biotech, epidemics, pharmacy benefit managers– that wrought major good and bad (mostly bad) cultural and regulatory changes (including the Hatch-Waxman Act and the Orphan Drug Act); plus the family battles following the sudden death of Arthur Sackler.

Killers of the Flower Moon / Heist

The First Book of the Week is “Killers of the Flower Moon, The Osage Murders and the Birth of the FBI” by David Grann, published in 2017. This volume described in suspenseful anecdotes– a political, social and cultural system suffused with evil– and it highlighted what happened to just one of countless families whose members were victims of the conspiracy.

In 1870, the Osage Native Americans were forced by light-skinned Americans to flee from their homeland in Kansas, to wasteland in northeastern Oklahoma. In 1893, the United States government’s Indian Affairs Department ordered that all children on the Osage reservation attend school. One consequence was that the young people in the area adopted the ways of the “white man.”

On September 16, 1893, the U.S. government shot a gun to kick off a land-grab. The Cherokee Outlet, territory bordering on the Osage’s that was bought by the U.S. government, was handed over to the Cherokees on a first-claimed via physical presence, first-owned basis.

About 42,000 members of the Cherokee nation waited on the border for days until the appointed time of the free-for-all. The fight for land ended in a massacre galore. The government didn’t bother to repeat the above process with the Osage reservation.

Yet, by the very early 1900’s, oil was discovered on the Osage’s land; this opened a Pandora’s box. In 1912, the Department of the Interior auctioned off the then-super-valuable parcels, to which the Osage had mineral rights. The Osage became millionaires overnight, paid royalties by the oil barons.

The local (white) politicians of the oil-rich lands stuck like leeches to the Osage residents, under the guise of regulating commerce. They deemed that (white) guardians of the property be appointed for full-blooded Osage people, as the Native Americans weren’t sufficiently educated or competent to manage their own money. Unsurprisingly, the guardians were thieves and worse.

Read the book to learn about a statistics-defying (but not uncommon among the Osage) rash of deaths (by poisonings, shootings and explosives) that occurred in one Osage family due to the “system” and the growing-pains the Wild West experienced as it evolved into a civilized, law-abiding society with the help of a national law enforcement organization now known as the FBI.

A more recent example of exploitation of Native Americans was described in the Second Book of the Week, “Heist, Superlobbyist Jack Abramoff, His Republican Allies, and the Buying of Washington” by Peter H. Stone, published in 2006. Yet again, the hypothetical board game “Survival Roulette” could be applied to this scandal: Native American Exploitation Edition (See “Highly Confident” post).

There have been countless ultimate winners of this game through the centuries: all the people never caught for committing crimes against Native Americans. The vast majority have gone unpunished, including several people mentioned in the book, whose names have already faded from the public’s memory.

However, the most famous hypothetical losers of the game in this book were lobbyists Jack Abramoff and Michael Scanlon, and Congressman Tom DeLay. Instead of a Monopoly board, in keeping with the casino theme, the central structure of the game could be an actual roulette wheel, whose ball could land on spaces that describe the financial crimes of: bribery, money laundering, fraud, disclosure failures and influence peddling. Plus tax evasion. Just for good measure.

In short, with Abramoff as the ringleader, during the course of three years, the gang milked six Native American tribes for $82 million– that paid for political bribes, funding for a school, lavish gifts, and entertainment and recreation expenses– disguised as lobbying and public relations services on behalf of the tribes.

In this slim volume, the author dispensed with suspense by revealing up front that, when they got caught, Abramoff and his sidekick Scanlon accepted plea deals for their unethical opportunism, unconscionable greed and unmitigated hubris. The author then failed to explain why the Texas state government closed a casino run by the Tigua Indians in February 2002, but did explain later on.

Nevertheless, the story thereafter unfolded in more or less chronological order, starting with backstory from the 1990’s. The Tigua casino actually stayed closed, despite Abramoff’s fat fee, part of which he circuitously funneled through nonprofit organizations that ended up as political donations, and paid for a luxurious golf vacation in the United Kingdom for himself and his cronies.

Abramoff’s shamelessness knew no bounds. He had his friends, in order to service one of his tribal clients, marshal support from the likes of the Christian Coalition to convince the U.S. government that gambling was against their religion, and a reason to close the Tigua casino. At the same, he was lobbying on behalf of the Tiguas through illegal means, to reopen the casino (!) For that, he made megabucks from both sides.

Abramoff also helped to quash legislation that would have taxed his Choctaw client, and would have imposed tougher labor laws on his offshore client that manufactured clothing in the Marianas.

Kevin Sickey, who represented an Indian tribe that hired Abramoff, described the lobbyist’s propaganda thusly: “They exaggerated political threats and they exaggerated economic threats. Then they exaggerated their ability to deal with threats.”

Read the book to learn what led to the start of investigations by the Senate Indian Affairs Committee and the Justice Department; Abramoff’s and Scanlon’s early-career adventures; and details of their and others’ punishments, among other nothing-new-under-the-sun type political opportunism, greed and hubris.

As an aside, the dollar value of political wrongdoing has reached dizzying heights in the past few decades, and it has been the same kind of wrongdoing, over and over again– committed mostly by alpha males. People who have an insatiable need for power and money apparently never learn from others whose stories have been well-publicized!


The Chief – BONUS POST

The Bonus Book of the Week is “The Chief, The Life and Turbulent Times of Chief Justice John Roberts” by Joan Biskupic, published in 2019. This slightly redundant biography described prominent U.S. Supreme-Court cases in detail, explaining them for laypeople. Most of the cases revolved around issues with which the United States continues to grapple, especially various kinds of discrimination.

Born in January 1955 in western New York State, Roberts and his family moved to Indiana near the Illinois border when he was about eight years old. He turned into a staunch conservative Republican.

The burning question that must be answered in any given case, that would determine whether favoritism or compensation should be given to the victims of discrimination, is whether, as a group, the victims– having been oppressed for so long– have caught up to the rest of society, with regard to the case’s area of life covered; education, housing, employment, political elections, financial dealings and other day-to-day situations.

In the applicable areas of life, whether and how much discrimination still exists is of course, extremely subjective (given the anecdotal evidence and propaganda wars from both sides). Each case needs to be decided on an individual basis because the times are continually changing. If the victims have yet to catch up, it is because one thing leads to another. If for decades, they’ve been rejected from, say, colleges based on their skin color, they’re at a disadvantage when it comes to employment opportunities, which leads to financial disadvantages and a slew of other lifestyle limitations. It’s not just a matter of compensating victims for past wrongs against them– the wrongs (if there were wrongs) held them back from being treated equally with others for decades longer.

It is impossible to require truly color-blind acceptance policies, however. And of course, there’s always that lingering uncertainty whether the college applicants were accepted more for– when compared with their peers– their potential success in furthering their education, than for their skin color.

Roberts claimed the Supreme Court was nonpartisan in handing down decisions. But– the Court has been divided 4-4 or 5-4 practically all the time in famous cases, because each of its presiding justices has consistently subscribed to a particular political persuasion in his or her opinions.

Further, appointments of Supreme Court Justices (or lack thereof) have been fiercely political in recent decades. “From the start of Obama’s presidency [Mitch] McConnell had put up hurdles to Obama’s lower Court nominations, ensuring, for instance, that not a single appointment was confirmed to the D.C. Circuit in Obama’s first term.”

Read the book to learn of the many ways Roberts made known his political beliefs through his Court pronouncements.

34 Days – BONUS POST

The Bonus Book of the Week is “34 Days, Israel, Hezbollah, and the War in Lebanon” by Amos Harel and Avi Issacharoff, published in 2008. This book described the summer 2006 war between Israel and Hezbollah in Lebanon, during which about a thousand people died.

In 1982, Israel launched a war with the Palestine Liberation Organization (PLO) to drive it out of Lebanon. Hezbollah started to arrive there after the PLO left. President Ronald Reagan of the United States– which for years had been an intermediary truce-negotiating party to Middle Eastern unrest– put discussions about foreign troop withdrawal (Syrian, American, Israeli) from Lebanon on the back burner after that first war ended.

Hezbollah, comprised of Shiites, a sect of Islam, originally formed in Iran. It acquired power in the Lebanese government by electing Parliamentarians beginning in 1992. The group was allowed to keep its weaponry through the years, even though it was allegedly provoking border skirmishes by abducting soldiers.

The second war started in mid-July 2006, when Israel reacted with exaggerated hostility to the abduction of two soldiers by Hezbollah terrorists at the Lebanese border. The Israeli military wanted to entirely wipe out the terrorist group.

Ehud Olmert– Israeli president since 2000, and the “defense” minister he appointed, Amir Peretz, went hog-wild. They agreed with hawkish military leaders to not only take out Hezbollah’s Syrian-supplied Katyusha rockets on the ground before they could be deployed, but to blast transportation, media and energy hubs in Lebanon with sophisticated weaponry, knowing this action would kill many civilians.

Arab states nearby (but not Syria)– Saudi Arabia, Egypt, Jordan and the Gulf Emirates– were silently cheering for Israel to take out Hezbollah, a move related to preventing Iran from developing nuclear weapons. The West chastised Israel for its aggression, although it itself was at that moment continuing to violate the Geneva Convention in Iraq, etc.

Read the book to learn details of the unnecessary parting shot at the war’s end taken by Israel, which handled the war incompetently at best and evilly at worst, that caused many needless deaths (especially civilian), with, unsurprisingly, “… both sides racing to ensure their victory and to perpetuate their own narrative of the war” to the media and the public.