Appointment at the Ends of the World

The Book of the Week is “Appointment at the Ends of the World, Memoirs of A Wildlife Veterinarian” by William B. Karesh, published in 1999.

The American author traveled to exotic locales to participate in conservation projects for the Wildlife Conservation Society and other international aid organizations, which manage and study animals and their habitats and resources in tens of countries. He got special permission from governments to bring a vast quantity of supplies and equipment to jungles, savannas, forests, etc.

The author spent part of the year at the Bronx Zoo. In 1995, he flew to northeastern Zaire to treat an infection in one okapi, and was driven hours to enter a safari park to study white rhinos. His luggage weighed 220 pounds. It was full of sampling supplies (tubes, racks, pipettes, towels, etc.), drugs for the animals, immobilization / capture equipment (like oxygen and carbon dioxide tanks, cartridges and numerous accessories), animal-handling and marking equipment (clips, cards, etc.), books, cords, converters and other miscellaneous items, and camping gear. Not to mention, clothing.

In Bolivia, the author performed various tests to measure the amount of environmental contaminants in the bodies of wild caimans because they live thirty to forty years. Examining the reptiles at intervals can indicate changes in their aquatic habitats.

In Cameroon, the author encountered shenanigans. For, he had to hire local guides; the leader (a native Nigerian) was fluent in the English language, and allegedly skilled at finding forest-elephants. The leader led the group on a “wild-goose chase” for weeks. When the group finally got close enough to one animal at which to shoot a radio-transmitter dart and a tranquilizer-dart, the leader missed twice shooting the former dart. The adrenaline was pumping in the people too, because the territorial elephants can crush humans to death.

The author conceded that he was doing an extremely controversial job. He and his employers threw vast amounts of resources at animals to save their lives or help them survive. He behaved like a Darwin-award candidate at times, and at other times, ironically, over the long run– made conditions worse for his charges. Ecotourism, too, whose goal is profiteering (rather than sincere concern for endangered species)– has taken its toll on disrupting animal habitats.

The phrase “white savior complex” could now be applied to the way wealthy people condescendingly think that saving a few individuals will solve the extremely complex problems of survival faced by all of the earth’s organisms. It is fair to say that in recent decades, money has actually corrupted global efforts to save lots of them.

To boot, the decades wasted searching for aliens and Bigfoot have just muddied the waters more. Incidentally, as is well known, on the TV show Star Trek, the aliens always speak perfect American English. Lastly, people who bother animals to get attention are still a “thing” on the idiot box, despite Steve Irwin’s cautionary tale. Anyway, read the book to learn a wealth of additional details on the author’s career, and how it shaped his lifestyle.

Surviving the Extremes – BONUS POST

The Bonus Book of the Week is “Surviving the Extremes, A Doctor’s Journey to the Limits of Human Endurance” by Kenneth Kamler, M.D., published in 2004.

The author, a medical doctor, described people’s experiences: in the Amazon jungle, while deep-sea diving, on Mount Everest, in the desert, on the high seas, and in a spaceship. The adventurers were subjected to life-threatening conditions at every turn (by choice— they were Darwin award candidates), but possessed expertise and technology that bettered their chances of survival. Their local-area employees possessed the physical characteristics advantageous for survival because those employees had become adapted to the harsh conditions over the course of generations. Some people did die, though. However, the author failed to specify the time-frames of the above scenarios. The introduction of new technologies, and discoveries have probably prevented or mitigated some of those kinds of disasters, since the book’s writing.

One point the author made, concerns the relationship between the human brain and society. A society can regress when an influential leader in a position of power breaks a taboo. His followers will copy him and rationalize away the sin. It then becomes easier to break additional taboos. Eventually, fairness and morality go out the window, because human brains actually adopt a more primitive way of thinking.

The cerebral cortex of the brain guides the ethics of behavior, but the amygdala takes over when tempers flare, and impulse control decreases. If the amygdalas of a significant portion of the population are activated via vicious political rumors, such as:

  • Biden’s going to pack the U.S. Supreme Court!
  • Medicare’s going to be privatized!
  • Biden’s senile and Harris is going to take over the country!
  • The Republicans are going to win back the House in the 2022 midterm elections!

the nation’s behavior regresses. Enough said.

Anyway, read the book to learn a lot about the roles physiology, biochemical processes, psychology and man-made resources play in survival when humans are present in places that tax their limitations.

Pharma

The Book of the Week is “Pharma– Greed, Lies, and the Poisoning of America” by Gerald Posner, published in 2020.

In 2016, the “superbug” Enterobacteriaceae turned out to be resistant to 26 different antibiotics. About half of patients who contract it, die. There are a bunch of other similar bacteria in the world. The author warned that in the future, a bacterial pandemic was on the way, for which there would be no antibiotic cure. Apparently, there can be a viral pandemic, too– one that cannot be treated with antibiotics at all.

For, antibiotics kill only bacteria, if that. Yet, in the United States, for decades, antibiotics have been prescribed to treat (mild!) viral illnesses. That is one major reason that superbugs have become a trend. And there has been an epidemic of diabetes type II. And many other adverse consequences.

Anyway, the author recounted the history of big-name drug companies, which began selling morphine to soldiers during the American Civil War. In the second half of the 1800’s, Pfizer, Squibb, Wyeth, Parke-Davis, Eli Lilly, and Burroughs-Wellcome began mostly as family proprietorships that sold highly addictive, unregulated drugs. Bayer produced heroin in 1898. The twentieth century saw Merck put cocaine in its products; other companies jumped on the cocaine bandwagon.

In 1904, the head of the United States government’s Bureau of Chemistry, Harvey Wiley, was concerned about contaminants in the nation’s food supply. Consumers were being sickened by chemicals that were supposed to retard spoilage or enhance the appeal of foods. They included, but were far from limited to: borax, salicylic acid, formaldehyde, benzoate, copper sulfate and sulfites. Trendy patent medicines were also doing harm to consumers. The word “patent” gave the impression of approval or regulation of some kind, but actually meant nothing.

Through the first third of the twentieth century, the government continued categorizing, monitoring and taxing drugs, but the pharmaceutical companies continued using trade groups and legal strategists to protect their profits. The 1930’s saw the big drug companies start research laboratories. Finally in 1938, the government established the Food and Drug Administration, and began to require extensive product-testing and labeling, and factory inspections. That same year, the Wheeler-Lea Act prohibited false advertising of drugs, except for previously manufactured barbiturates and amphetamines.

After Pearl Harbor was attacked in December 1941, America sought to manufacture penicillin in volume. For, the newly introduced antibiotic would be very helpful to the war wounded. But the drug’s fermentation process required a rare ingredient. In spring 1942, one patient who had friends in high places was cured. That largely used up the penicillin supply in the entire country. Other kinds of antibiotics were produced in the next decade, but their profitability was hampered by the bureaucratic processes of patent applications and FDA approval applications.

In the late 1940’s, Arthur Sackler and his brothers founded a family drug-company dynasty. The author revealed excessive trivia from FBI files on them and other greedy characters whose tentacles pervaded all businesses that could help sell (translation: maximize profits of) the family’s healthcare goods and services. This meant consulting, advertising, publishing, charities, public relations, database services, etc. The parties failed to disclose countless conflicts of interest.

In the early 1950’s, drug companies successfully lobbied the U.S. Patent and Trademark Office to allow drugs with strikingly similar molecular structures to be deemed different so that they could be granted separate patents. A higher number of drugs could then be rushed to market sooner, and make the most money.

In 1952, farmers fed Pfizer’s antibiotics to their animals so that they grew bigger (both Pfizer and the animals). In the mid-1950’s, Pfizer, Lederle, Squibb, Bristol and Upjohn engaged in an illegal tetracycline price-fixing scheme. They reaped hundreds of millions of dollars in earnings. The FDA chief was in Sackler’s back pocket. So when violations came to light, the FTC and FDA gave the offenders a slap on the wrist. However, senator Estes Kefauver was a thorn in their side.

Kefauver led an investigation as to why America’s drug prices were so excessively high when compared with those in other nations. In fighting back, the drug industry smeared Kefauver as a liberal pinko, claiming he had designs on forcing socialized medicine on the United States. The nineteen drugmakers under the gun gave bogus excuses. The real reason is that America’s drug prices and patents are subjected to minimal or no regulation, unlike everywhere else.

In 1956, Americans were told they were stressed, but a wonder drug called “Miltown” would help calm them down. The mild tranquilizer became a best-seller, until it was counterfeited and appeared on the black market, and its adverse side effects gave it bad publicity. Oh, well.

Then in the 1960’s came the culture-changing birth control Pill, and Valium– also called “mother’s little helper” that was marketed as a weight-loss aid. The next game-changer was thalidomide. Kefauver used the worldwide backlash against this drug to push through some drug safety and effectiveness regulation in the United States in 1963. For a change. Even so, in 1972, when the U.S. Supreme Court confirmed certain regulatory powers conferred on the FDA, drugmakers merely sought additional markets for their products on other continents.

In 1976, there was a swine flu epidemic in America. Healthcare companies were reluctant to develop a vaccine for it, fearing an orgy of litigation from victims if any harm was done. So the government unwisely agreed to foot any legal bills. Sure enough, some vaccine recipients developed cases of Guillain Barre syndrome, and neurological complications. The (taxpayer-funded) Justice Department took the hit. Other parties piled on. “The CDC had exploited ‘Washington’s panic’ to ‘increase the size of its empire and multiply its budget.’ “

Moving on, the author told the whole sordid story of the “opioid crisis” in America. In a nutshell: in May 2002, Purdue Pharma, maker and unethical marketer of OxyContin, hired Rudy Giuliani’s firm to defend it against the firestorm from its host of illegal activities. The firm collected a $3 million fee per month. Purdue collected $30 million per week from OxyContin sales. To be fair, Purdue and the Sackler family were the poster-scapegoats of the crisis. Numerous other parties aided and abetted them: other pharmaceutical companies, doctors, FDA bureaucrats, and pain management “experts” and pharmacists. The far-reaching consequences have caused a lot of trouble for society as a whole in the areas of: increased healthcare costs, criminal justice, social services, drug rehabilitation services, lost productivity and earnings, etc.

Read the book to learn an additional wealth of details and the details of wealth of the healthcare industry’s evolution into a hegemonic legal behemoth / excessive profit center, in the form of a series of cautionary tales in various topic areas– drug advertising, blood donations, biotech, epidemics, pharmacy benefit managers– that wrought major good and bad (mostly bad) cultural and regulatory changes (including the Hatch-Waxman Act and the Orphan Drug Act); plus the family battles following the sudden death of Arthur Sackler.

Pertinent Post

“P” post.

Present pandemic’s politics produced:

  • propaganda
  • president-promotion
  • provisions-portioning predicaments
  • panic
  • profiteering
  • paranoia
  • patronage pigs
  • pissed, persecuted people
  • poseurs
  • puerile politicians (petty power plays)
  • pained physicians
  • problematic prescriptions
  • pressured paramedics
  • pestered practices
  • poor populations
  • plus, predictably:

POPPYCOCK.

Pink Boots and A Machete

The Book of the Week is “Pink Boots and A Machete, My Journey From NFL Cheerleader to National Geographic Explorer” by Mireya Mayor, published in 2011.

Mayor was born in February 1973 in Miami. While in her early twenties, she discovered her calling– primatologist / zoologist. An inspirational college professor helped her apply for a government grant to study a monkey in Guyana.

Thereafter, she braved infinite life-threatening dangers and primitive and uncomfortable conditions (like poor sanitation, and an extremely limited and at times– disgusting diet, and unbearable heat, to name three) on dozens of expeditions for weeks or months in obscure places to observe various animals in their natural habitats.

In the Congo, there were killer bees. In the jungle in Guyana, there were itinerant miners who were robbers and rapists; piranhas, malarial mosquitoes, tarantulas, vampire bats, ticks, leeches, etc. The author had to sleep in a hammock to avoid poisonous snakes on the ground.

In June 1997 in Madagascar, “Every visit to a village required a rum-soaked meeting with tribal elders that lasted through the night, occasionally for days.” While seeking a specific species of lemur in an animal reserve (that was not exactly a tourist attraction), she was bitten by a small scorpion and swarmed by wasps. Hundreds of cockroaches nestled in her pants legs overnight, shocking her when she went to put them on.

On another occasion in Guyana, she and her crew collected flora and fauna specimens from a mountain on which they camped (on the edge of a cliff, basically) in a “… flimsy sheet of nylon attached to the rock face by a single, six-inch steel pin.”

In Namibia, she was one of eight people who lifted the six-foot, six hundred pound neck of a tranquilized giraffe. The whole animal weighed approximately eighteen hundred pounds. The goal was to herd giraffes into a trailer to help them mate and reproduce.

On another occasion in Madagascar, when a mudslide from a monsoon prevented their hired truck from going any farther, she, another scientist and expensive porters (strong men) had to hike hours and hours with heavy gear, dozens of bags, crates and a generator to a campsite.

Mayor related that on another occasion in the Congo, “I woke up in an unusually good mood, considering it was 5am and I still had the worm [in the foot], the filarial bites, and the infected tick bite… Repeated hot soaks and antibiotic treatments finally banished it [the tick bite].”

Read the book to learn of the new species Mayor co-discovered, how she fared on a reality show, the kinds of issues she dealt with for being female in a male-dominated field, and much more.

Half-Life

The Book of the Week is “Half-Life, The Divided Life of Bruno Pontecorvo, Physicist or Spy” by Frank Close, published in 2015. The author himself was a physicist, so he interspersed physics concepts with the evolution of the development of nuclear technology and its major players. This book was written for readers who would like to learn some nuclear physics, and/or those readers curious about the people involved in Cold War / nuclear physics mysteries.

However, Close made an error, spelling “Lise Meitner” as “Lisa Meitner.” Additionally, since the author was neither a historian nor American (he was British) he was mistaken in declaring, “For supporters of communism in the West, this [the autumn 1956 Hungarian uprising which was bloodily crushed by the Soviets] was probably the most serious crisis of conscience since the Soviet pact with the Nazis in 1939.” Actually, in early 1956, Khrushchev revealed Stalin’s horrific crimes to the world. Americans, especially those who considered themselves Social Democrats, were thrown for a loop ideologically, and became bitterly conflicted in their own minds, and with each other.

Anyway, born in Italy in August 1913, Pontecorvo was the fourth of eight children. In 1931, he transferred from the University of Pisa to that of Rome for his third year of physics studies, mentored by Enrico Fermi. Knowledge of particle physics was in its infancy. Pontecorvo and other scientists jointly filed a patent in autumn 1935 in connection with experiments with neutrons and hydrogen.

The year 1936 saw Pontecorvo flee to Paris after Mussolini cracked down on Jews’ liberty. He studied with Frederic and Irene Joliot-Curie. He was turned on to Communist ideology by his cousin. They attended meetings and rallies.

By the late 1930’s, physicists (and governments) of different nations such as Germany, France, Italy, the USSR, etc. started to realize how important nuclear processes were for creating future weapons of mass destruction– instrumental for their respective homelands’ national security. Beginning in the summer of 1940, nuclear research became secret in the United States. Scientific journals would no longer publish articles on that topic.

The USSR did not lack for brains, but for uranium in the early 1940’s. Beginning in summer 1942 in Moscow, the Soviets worked on an atomic bomb. But scientists in the United Kingdom had a head start, having begun their work the previous year. In December 1942, the United States started the Manhattan Project.

By the end of the 1940’s, having done nuclear research in Tulsa in Oklahoma, the Northwest Territories in Canada and in Harwell in England, Pontecorvo was planning to move himself, his wife and three sons to Liverpool to become a physics professor. The British intelligence service MI5 secretly pushed him in that direction. As is well known, the United States was gripped by anti-Communist hysteria, with the arrests of spies Klaus Fuchs, David Greenglass and the Rosenbergs.

The summer of 1950 saw the Pontecorvo family take a summer vacation in France, Switzerland, and the Italian countryside. There is circumstantial evidence that he met with his Communist cousin and suddenly, all bets were off.

Read the book to learn the fate of the family, the contributions made to science by the scientist, learn why he neither won the Nobel Prize nor collected royalties on the aforementioned patent, and much more.