Category: Science-Biology/Chemistry/Physics

Pharma

The Book of the Week is “Pharma– Greed, Lies, and the Poisoning of America” by Gerald Posner, published in 2020.

In 2016, the “superbug” Enterobacteriaceae turned out to be resistant to 26 different antibiotics. About half of patients who contract it, die. There are a bunch of other similar bacteria in the world. The author warned that in the future, a bacterial pandemic was on the way, for which there would be no antibiotic cure. Apparently, there can be a viral pandemic, too– one that cannot be treated with antibiotics at all.

For, antibiotics kill only bacteria, if that. Yet, in the United States, for decades, antibiotics have been prescribed to treat (mild!) viral illnesses. That is one major reason that superbugs have become a trend. And there has been an epidemic of diabetes type II. And many other adverse consequences.

Anyway, the author recounted the history of big-name drug companies, which began selling morphine to soldiers during the American Civil War. In the second half of the 1800’s, Pfizer, Squibb, Wyeth, Parke-Davis, Eli Lilly, and Burroughs-Wellcome began mostly as family proprietorships that sold highly addictive, unregulated drugs. Bayer produced heroin in 1898. The twentieth century saw Merck put cocaine in its products; other companies jumped on the cocaine bandwagon.

In 1904, the head of the United States government’s Bureau of Chemistry, Harvey Wiley, was concerned about contaminants in the nation’s food supply. Consumers were being sickened by chemicals that were supposed to retard spoilage or enhance the appeal of foods. They included, but were far from limited to: borax, salicylic acid, formaldehyde, benzoate, copper sulfate and sulfites. Trendy patent medicines were also doing harm to consumers. The word “patent” gave the impression of approval or regulation of some kind, but actually meant nothing.

Through the first third of the twentieth century, the government continued categorizing, monitoring and taxing drugs, but the pharmaceutical companies continued using trade groups and legal strategists to protect their profits. The 1930’s saw the big drug companies start research laboratories. Finally in 1938, the government established the Food and Drug Administration, and began to require extensive product-testing and labeling, and factory inspections. That same year, the Wheeler-Lea Act prohibited false advertising of drugs, except for previously manufactured barbiturates and amphetamines.

After Pearl Harbor was attacked in December 1941, America sought to manufacture penicillin in volume. For, the newly introduced antibiotic would be very helpful to the war wounded. But the drug’s fermentation process required a rare ingredient. In spring 1942, one patient who had friends in high places was cured. That largely used up the penicillin supply in the entire country. Other kinds of antibiotics were produced in the next decade, but their profitability was hampered by the bureaucratic processes of patent applications and FDA approval applications.

In the late 1940’s, Arthur Sackler and his brothers founded a family drug-company dynasty. The author revealed excessive trivia from FBI files on them and other greedy characters whose tentacles pervaded all businesses that could help sell (translation: maximize profits of) the family’s healthcare goods and services. This meant consulting, advertising, publishing, charities, public relations, database services, etc. The parties failed to disclose countless conflicts of interest.

In the early 1950’s, drug companies successfully lobbied the U.S. Patent and Trademark Office to allow drugs with strikingly similar molecular structures to be deemed different so that they could be granted separate patents. A higher number of drugs could then be rushed to market sooner, and make the most money.

In 1952, farmers fed Pfizer’s antibiotics to their animals so that they grew bigger (both Pfizer and the animals). In the mid-1950’s, Pfizer, Lederle, Squibb, Bristol and Upjohn engaged in an illegal tetracycline price-fixing scheme. They reaped hundreds of millions of dollars in earnings. The FDA chief was in Sackler’s back pocket. So when violations came to light, the FTC and FDA gave the offenders a slap on the wrist. However, senator Estes Kefauver was a thorn in their side.

Kefauver led an investigation as to why America’s drug prices were so excessively high when compared with those in other nations. In fighting back, the drug industry smeared Kefauver as a liberal pinko, claiming he had designs on forcing socialized medicine on the United States. The nineteen drugmakers under the gun gave bogus excuses. The real reason is that America’s drug prices and patents are subjected to minimal or no regulation, unlike everywhere else.

In 1956, Americans were told they were stressed, but a wonder drug called “Miltown” would help calm them down. The mild tranquilizer became a best-seller, until it was counterfeited and appeared on the black market, and its adverse side effects gave it bad publicity. Oh, well.

Then in the 1960’s came the culture-changing birth control Pill, and Valium– also called “mother’s little helper” that was marketed as a weight-loss aid. The next game-changer was thalidomide. Kefauver used the worldwide backlash against this drug to push through some drug safety and effectiveness regulation in the United States in 1963. For a change. Even so, in 1972, when the U.S. Supreme Court confirmed certain regulatory powers conferred on the FDA, drugmakers merely sought additional markets for their products on other continents.

In 1976, there was a swine flu epidemic in America. Healthcare companies were reluctant to develop a vaccine for it, fearing an orgy of litigation from victims if any harm was done. So the government unwisely agreed to foot any legal bills. Sure enough, some vaccine recipients developed cases of Guillain Barre syndrome, and neurological complications. The (taxpayer-funded) Justice Department took the hit. Other parties piled on. “The CDC had exploited ‘Washington’s panic’ to ‘increase the size of its empire and multiply its budget.’ “

Moving on, the author told the whole sordid story of the “opioid crisis” in America. In a nutshell: in May 2002, Purdue Pharma, maker and unethical marketer of OxyContin, hired Rudy Giuliani’s firm to defend it against the firestorm from its host of illegal activities. The firm collected a $3 million fee per month. Purdue collected $30 million per week from OxyContin sales. To be fair, Purdue and the Sackler family were the poster-scapegoats of the crisis. Numerous other parties aided and abetted them: other pharmaceutical companies, doctors, FDA bureaucrats, and pain management “experts” and pharmacists. The far-reaching consequences have caused a lot of trouble for society as a whole in the areas of: increased healthcare costs, criminal justice, social services, drug rehabilitation services, lost productivity and earnings, etc.

Read the book to learn an additional wealth of details and the details of wealth of the healthcare industry’s evolution into a hegemonic legal behemoth / excessive profit center, in the form of a series of cautionary tales in various topic areas– drug advertising, blood donations, biotech, epidemics, pharmacy benefit managers– that wrought major good and bad (mostly bad) cultural and regulatory changes (including the Hatch-Waxman Act and the Orphan Drug Act); plus the family battles following the sudden death of Arthur Sackler.

Pertinent Post

“P” post.

Present pandemic’s politics produced:

  • propaganda
  • president-promotion
  • provisions-portioning predicaments
  • panic
  • profiteering
  • paranoia
  • patronage pigs
  • pissed, persecuted people
  • poseurs
  • puerile politicians (petty power plays)
  • pained physicians
  • problematic prescriptions
  • pressured paramedics
  • pestered practices
  • poor populations
  • plus, predictably:

POPPYCOCK.

Half-Life

The Book of the Week is “Half-Life, The Divided Life of Bruno Pontecorvo, Physicist or Spy” by Frank Close, published in 2015. The author himself was a physicist, so he interspersed physics concepts with the evolution of the development of nuclear technology and its major players. This book was written for readers who would like to learn some nuclear physics, and/or those readers curious about the people involved in Cold War / nuclear physics mysteries.

However, Close made an error, spelling “Lise Meitner” as “Lisa Meitner.” Additionally, since the author was neither a historian nor American (he was British) he was mistaken in declaring, “For supporters of communism in the West, this [the autumn 1956 Hungarian uprising which was bloodily crushed by the Soviets] was probably the most serious crisis of conscience since the Soviet pact with the Nazis in 1939.” Actually, in early 1956, Khrushchev revealed Stalin’s horrific crimes to the world. Americans, especially those who considered themselves Social Democrats, were thrown for a loop ideologically, and became bitterly conflicted in their own minds, and with each other.

Anyway, born in Italy in August 1913, Pontecorvo was the fourth of eight children. In 1931, he transferred from the University of Pisa to that of Rome for his third year of physics studies, mentored by Enrico Fermi. Knowledge of particle physics was in its infancy. Pontecorvo and other scientists jointly filed a patent in autumn 1935 in connection with experiments with neutrons and hydrogen.

The year 1936 saw Pontecorvo flee to Paris after Mussolini cracked down on Jews’ liberty. He studied with Frederic and Irene Joliot-Curie. He was turned on to Communist ideology by his cousin. They attended meetings and rallies.

By the late 1930’s, physicists (and governments) of different nations such as Germany, France, Italy, the USSR, etc. started to realize how important nuclear processes were for creating future weapons of mass destruction– instrumental for their respective homelands’ national security. Beginning in the summer of 1940, nuclear research became secret in the United States. Scientific journals would no longer publish articles on that topic.

The USSR did not lack for brains, but for uranium in the early 1940’s. Beginning in summer 1942 in Moscow, the Soviets worked on an atomic bomb. But scientists in the United Kingdom had a head start, having begun their work the previous year. In December 1942, the United States started the Manhattan Project.

By the end of the 1940’s, having done nuclear research in Tulsa in Oklahoma, the Northwest Territories in Canada and in Harwell in England, Pontecorvo was planning to move himself, his wife and three sons to Liverpool to become a physics professor. The British intelligence service MI5 secretly pushed him in that direction. As is well known, the United States was gripped by anti-Communist hysteria, with the arrests of spies Klaus Fuchs, David Greenglass and the Rosenbergs.

The summer of 1950 saw the Pontecorvo family take a summer vacation in France, Switzerland, and the Italian countryside. There is circumstantial evidence that he met with his Communist cousin and suddenly, all bets were off.

Read the book to learn the fate of the family, the contributions made to science by the scientist, learn why he neither won the Nobel Prize nor collected royalties on the aforementioned patent, and much more.

The Last Man Who Knew Everything

The Book of the Week is “The Last Man Who Knew Everything, The Life and Times of Enrico Fermi, Father of the Atomic Age” by David N. Schwartz, published in 2017.

Born to a wealthy family in September 1901 in Italy, Fermi was mentored in science by a colleague of his father, who worked for the railroad. This, after suffering the trauma of having his older brother die unexpectedly having throat surgery in 1914.

Fermi had a photographic memory, which helped to make him a brilliant student in mathematics and physics from studying textbooks. He was required to learn German too, to keep abreast of developments in the scholarly journals.

Fermi eventually became a physics professor at the University of Rome. His teaching gig, which he was also really good at, lasted from 1926 to 1938. He married in July 1927 and several years later, he wrote, and his wife edited and translated, a high school physics textbook that became part of the standard high school curriculum in Italy.

Quantum statistical mechanics was his specialty. Athleticism was another. Fiercely competitive, he always outdid his colleagues in hiking and climbing the hills around Rome. He became well traveled, thanks to attendance at international physics conferences. Some were hosted in the United States, which had better research funding than his native country.

By the late 1920’s, Fermi had cofounded a world-class nuclear physics research institute in Rome. The first entering class consisted of three graduate students. The younger generation was reflecting on new quantum theories to which the old-school Italian physicists were resistant. Fermi was in the former group.

In spring 1929, Mussolini selected members, of which Fermi was one, for an elite scientific society. He offered them big money so that they would do Italy proud (like academic and athletic scholarships bestowed upon fiercely competitive students, dispensed by elitist schools in the United States nowadays).

In the early 1930’s, Fermi supervised scientists who traveled internationally to different labs to learn from their fellow Europeans; yet they also competed with physicists at prestigious institutions in Berlin, Paris, Berkeley in California, and Cambridge in England.

In October 1934, Fermi’s team discovered that “…slowing down neutrons enhanced the radioactivity induced by neutron bombardment.” In connection therewith, he applied for a patent in Italy and the United States. He got a new lab.

By 1936, Mussolini was finding that invading Ethiopia was an expensive proposition. He began to depend on financial aid from Nazi Germany. By summer 1938, Hitler had control over ruining careers of Jews in licensed professions, civil servants, and white collar jobs in Italy.

In late 1938, after much red tape and worrisome scheming, Fermi and his wife (who had been deemed Jewish) escaped Italy first for the Nobel Prize ceremony in Stockholm, at which he took his trophy and money, and then for the United States. He ended up working at Columbia University.

At a Washington, D.C. conference in January 1939, physicists announced they had figured out how to produce fission, the process required to detonate an atomic bomb. Some were concerned that if Hitler’s scientists got hold of such knowledge, he would order mass destruction of his enemies before they could stop him. Fermi felt there was a low probability that Germany could build such a device. But Fermi was persuaded to share the thereafter-secret formula with the United States Navy. This would show his loyalty to America at a time when Italy was not exactly America’s ally.

Read the book to learn the parties involved with, locations of, trials and tribulations regarding, and Fermi’s role in the Manhattan Project; what Fermi did thereafter; and the Edward Teller/J. Robert Oppenheimer dispute, plus other physics-related occurrences up until Fermi’s death.